Cell Cycle Kinase Inhibitor

In collaboration with Pfizer, we identified a number of lead compounds that modulate the activity of key enzymes that regulate the cell cycle — the process whereby a single cell replicates itself and divides into two identical new cells. Mutations in genes that regulate the cell cycle are present in a majority of human cancers.

Pfizer is developing the most advanced compound in this program — PD 0332991, an oral, small molecule cyclin-dependent kinase 4/6 inhibitor, which entered clinical testing in September 2004. The compound is currently in Phase 2 clinical development.  If Pfizer commercializes this product, Onyx will receive milestone payments and royalties on worldwide sales.

Stock Quote (update every 15 minutes): As of 4:00pm - 5/20/2011

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