Clinical Pipeline

Nexavar (sorafenib) tablets

Liver Cancer

Locoregional therapy

Adjuvant

Kidney Cancer

Advanced Kidney Cancer

Adjuvant

Non-Small Cell Lung Cancer

First line, gemcitabine/cisplatin +/-

Third/Fourth line, monotherapy

Thyroid Cancer

Monotherapy

Breast Cancer

First/second line, gemcitabine or capecitabine +/-

First line, docetaxel or letrozole +/-

Ovarian Cancer

Maintenance

Colorectal Cancer

Combinations

Multiple Myeloma

Relapsed, lenalidomide/dexamethasone

Relapsed/Refractory, Monotherapy

Solid Tumor

Monotherapy

Cell Cycle Kinase Inhibitor

ONX 0801 (TS Inhibitor)

ONX 0803* (JAK inhibitor)

ONX 0805* (JAK inhibitor)

ONX 0912 (oral proteasome inhibitor)

ONX 0914 (immunoproteasome inhibitor)

* subject to option exercise